Across TCGA pan-cancer cohorts, OR2T4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR2T4’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where OR2T4 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2T4 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.
BRCA and PRAD are the cancer types where OR2T4 tumor–normal differential expression is most reproducible.