OR2T35

Across TCGA patient cohorts, OR2T35 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2T35-associated genes across cancer lineages are DEFB129, MIR365A, and RNA5SP426. Each is linked with OR2T35 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T35-to-partner and partner-to-OR2T35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by OR2T35-low versus OR2T35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T35→partner) and Y-score (partner→OR2T35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEFB129 →	+0.266	+3.840	<.001	.007	3	2
UCEC	MIR365A →	+0.668	+4.474	<.001	.002	3	1
UCEC	RNA5SP426 →	+0.385	+4.868	<.001	.004	3	1
UCEC	RNU6-188P →	+0.494	+4.262	.008	.003	3	1
UCEC	SNORD114-18 →	+0.653	+4.884	.001	<.001	3	1
UCEC	RNU6-61P →	+0.465	+4.146	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

DEFB129 by OR2T35 expression — UCEC

Explore this box plot interactively →