Across TCGA pan-cancer cohorts, OR2T35 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR2T35’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OR2T35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2T35 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KIRC and KICH are the cancer types where OR2T35 tumor–normal differential expression is most reproducible.