OR2M4

Across TCGA cell cohorts, OR2M4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR2M4-associated genes across cancer lineages are PFN3, IQCF6, and SKOR2. Each is linked with OR2M4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2M4-to-partner and partner-to-OR2M4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by OR2M4-low versus OR2M4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2M4→partner) and Y-score (partner→OR2M4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFN3 →	+0.166	+4.467	<.001	.004	3	2
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	SKOR2 →	+0.022	+4.736	<.001	.009	3	1
SKIN	SLC10A2 →	+0.004	+4.437	<.001	.004	3	1
LUNG_SCLC	OR14K1 →	+0.131	+4.269	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.054	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PFN3 by OR2M4 expression — LARGE_INTESTINE

Explore this box plot interactively →