OR2M4

Across TCGA pan-cancer cohorts, OR2M4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated OR2M4 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher OR2M4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR2M4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

KIRP, MESO, and THCA are the cancer types where OR2M4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.207	0.760	<.001	99	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	87	view →
THCA	DFS	Tertile	IV	0.163	0.837	<.001	87	view →
BLCA	OS	Tertile	All	0.174	0.620	.002	66	view →
LIHC	OS	Tertile	All	0.140	0.692	<.001	63	view →
BRCA	OS	Tertile	All	0.989	0.957	.009	42	view →
UCS	DFS	Tertile	All	0.163	0.459	.043	36	view →
HNSC	OS	Tertile	IV	0.859	0.391	.024	36	view →
KIRC	DFS	Tertile	IV	0.110	0.640	.001	30	view →
ACC	OS	Tertile	All	0.214	0.820	.006	24	view →
STAD	DFS	Tertile	All	0.424	0.730	.005	18	view →
LAML	DFS	Tertile	All	0.425	0.672	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

OR2M4–KIRP (OS)

Open the KIRP breakdown →