OR2B6

Across TCGA patient cohorts, OR2B6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR2B6-associated genes across cancer lineages are PKC-a_pS657, EGFR, and PCNA. Each is linked with OR2B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2B6-to-partner and partner-to-OR2B6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by OR2B6-low versus OR2B6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2B6→partner) and Y-score (partner→OR2B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a_pS657 →	-0.420	-3.459	.015	.004	3	2
SKCM	EGFR →	-0.149	-2.000	.041	.031	3	1
SKCM	PCNA →	+0.211	+3.000	.014	.034	3	1
SKCM	PR →	-0.089	-2.000	.029	.031	3	1
SKCM	XRCC1 →	+0.175	+2.000	.027	.031	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-3.308	.026	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PKC-a_pS657 by OR2B6 expression — SKCM

Explore this box plot interactively →