OR2B6

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, OR2B6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of OR2B6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where OR2B6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2B6 is over-expressed in tumor.

BLCA, HNSC, and LIHC are the cancer types where OR2B6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2B6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
BLCAAllIII,IV+0.594<.00111view →
HNSCAllIII,IV+0.515<.00111view →
LIHCAllIII,IV+0.466<.0019view →
KIRCMaleIII,IV+0.141<.0019view →
BRCAAllIII,IV+1.121<.0018view →
UCECAllII,III,IV+1.058<.0018view →
LUADMaleAll+0.533<.0018view →
STADAllAll+0.526<.0017view →
KIRPAllII,III,IV+0.169.0016view →
CHOLAllAll+1.335<.0015view →
LUSCAllAll+0.607<.0015view →
COADAllAll+0.193.0015view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

OR2B6–BLCA

Tumor-vs-normal expression box plot for OR2B6 RNA in BLCA.

Open the BLCA breakdown →

Exploration