OR1Q1

Across TCGA patient cohorts, OR1Q1 mutation is significantly associated with the RNA expression of many other genes, with 279 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR1Q1-associated genes across cancer lineages are PPP1R12BP1, RN7SL822P, and RNA5SP412. Each is linked with OR1Q1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1Q1-to-partner and partner-to-OR1Q1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R12BP1 grouped by OR1Q1-low versus OR1Q1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1Q1→partner) and Y-score (partner→OR1Q1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPP1R12BP1 →	+0.096	+2.227	<.001	<.001	3	3
LUSC	RN7SL822P →	+0.205	+5.548	<.001	.004	3	3
UCEC	RNA5SP412 →	+0.781	+3.382	.001	.004	3	2
CESC	AQP7P4 →	+0.033	+4.539	.001	.008	3	2
BLCA	RNU6-777P →	+0.395	+5.329	<.001	.006	3	2
LUSC	RNA5SP413 →	+0.998	+6.081	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 279 associations by consensus.

PPP1R12BP1 by OR1Q1 expression — SKCM

Explore this box plot interactively →