OR1Q1

Across TCGA pan-cancer cohorts, OR1Q1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of OR1Q1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR1Q1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR1Q1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, STAD, and LUSC are the cancer types where OR1Q1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR1Q1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.059	.003	6	view →
STAD	All	All	+0.086	.013	3	view →
LUSC	All	All	+0.068	.023	3	view →
KIRC	Male	III,IV	+0.028	.038	3	view →
LIHC	All	All	+0.017	.004	3	view →
BRCA	All	III,IV	−0.076	.036	2	view →
LUAD	Female	II,III,IV	+0.040	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

OR1Q1–HNSC

Open the HNSC breakdown →