OR1L8

Across TCGA patient cohorts, OR1L8 mutation is significantly associated with the RNA expression of many other genes, with 2,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L8-associated genes across cancer lineages are HIGD1AP2, BRK1, and RN7SKP260. Each is linked with OR1L8 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1L8-to-partner and partner-to-OR1L8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1AP2 grouped by OR1L8-low versus OR1L8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L8→partner) and Y-score (partner→OR1L8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HIGD1AP2 →	+0.203	+4.962	.006	.003	3	3
UCEC	BRK1 →	+0.412	+3.343	.002	.005	3	3
LUAD	RN7SKP260 →	+0.146	+4.748	<.001	.003	3	3
UCEC	SNRPD3 →	+0.423	+3.087	<.001	<.001	3	3
SKCM	RBM17 →	+0.318	+1.755	.002	.003	3	3
SKCM	MRPL47 →	+0.269	+1.816	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,106 associations by consensus.

HIGD1AP2 by OR1L8 expression — COAD

Explore this box plot interactively →