OR1L8

Across TCGA pan-cancer cohorts, OR1L8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of OR1L8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where OR1L8 RNA is repressed in tumor relative to normal tissue. In most cancer types OR1L8 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and LUSC are the cancer types where OR1L8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR1L8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.524	<.001	11	view →
KIRP	All	II,III,IV	−0.382	<.001	11	view →
LUSC	Female	II,III,IV	−0.702	<.001	8	view →
KIRC	All	II,III,IV	−0.203	<.001	8	view →
THCA	All	II,III,IV	−0.200	<.001	7	view →
BRCA	Female	II,III,IV	−0.201	<.001	6	view →
KICH	All	All	+1.189	<.001	5	view →
BLCA	All	All	−0.211	.002	5	view →
UCEC	All	All	−0.293	<.001	4	view →
COAD	All	All	−0.061	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

OR1L8–LUAD

Open the LUAD breakdown →