OR1L3

Across TCGA patient cohorts, OR1L3 mutation is significantly associated with the RNA expression of many other genes, with 4,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L3-associated genes across cancer lineages are DNM1P28, RPSAP67, and ZMYND19. Each is linked with OR1L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L3-to-partner and partner-to-OR1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNM1P28 grouped by OR1L3-low versus OR1L3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L3→partner) and Y-score (partner→OR1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DNM1P28 →	+0.148	+4.795	<.001	.001	3	2
LUSC	RPSAP67 →	+0.083	+3.781	.005	.007	3	2
UCEC	ZMYND19 →	+0.603	+3.119	<.001	<.001	3	2
UCEC	ZFYVE19 →	+0.390	+2.724	.005	.003	3	2
SKCM	PHB →	+0.461	+3.597	<.001	.001	3	2
UCEC	FAM166C →	-1.011	-3.416	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,438 associations by consensus.

DNM1P28 by OR1L3 expression — LUSC

Explore this box plot interactively →