OR1L3

Across TCGA pan-cancer cohorts, OR1L3 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated OR1L3 data layer compared with 4 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher OR1L3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR1L3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCEC show a favorable association.

THCA, ESCA, and UCEC are the cancer types where OR1L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	II,III,IV	0.629	0.857	.001	66	view →
ESCA	OS	Tertile	III,IV	0.877	0.347	.001	38	view →
UCEC	DFS	Tertile	IV	1.000	0.312	.003	36	view →
COAD	OS	Tertile	All	0.704	0.878	.001	36	view →
CESC	OS	Tertile	IV	1.000	0.240	.040	18	view →
KIRC	DFS	Tertile	All	0.646	0.822	.006	18	view →
BRCA	DFS	Tertile	III,IV	0.777	0.413	.015	12	view →
THYM	OS	Tertile	All	0.724	0.892	.039	12	view →
PAAD	DFS	Tertile	All	0.282	0.524	.027	9	view →
HNSC	DFS	Tertile	All	0.118	0.362	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

OR1L3–THCA (DFS)

Open the THCA breakdown →