OR1I1

Across TCGA patient cohorts, OR1I1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1I1-associated genes across cancer lineages are A-Raf_pS299, FOXO3a, and PR. Each is linked with OR1I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1I1-to-partner and partner-to-OR1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by OR1I1-low versus OR1I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1I1→partner) and Y-score (partner→OR1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.106	-1.807	.032	.027	3	2
UCEC	FOXO3a →	-0.093	-2.986	.026	.035	3	2
UCEC	PR →	-0.229	-3.169	.027	.019	3	2
UCEC	Shc_pY317 →	-0.162	-3.000	.009	.001	3	2
UCEC	EGFR_pY1068 →	-0.263	-3.584	.011	.002	3	1
UCEC	ER-alpha_pS118 →	-0.324	-2.321	.028	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

A-Raf_pS299 by OR1I1 expression — UCEC

Explore this box plot interactively →