OR1I1

Across TCGA pan-cancer cohorts, OR1I1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated OR1I1 data layer compared with 3 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher OR1I1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR1I1 expression acts as an unfavorable survival marker, although some lineages such as SARC show a favorable association.

CHOL, LIHC, and LUSC are the cancer types where OR1I1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.089	0.746	<.001	108	view →
LIHC	OS	Tertile	II,III,IV	0.123	0.719	<.001	81	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
KIRC	DFS	Tertile	IV	0.305	0.628	.021	30	view →
SKCM	DFS	Tertile	IV	0.032	0.477	<.001	21	view →
SCLC	OS	Tertile	All	0.055	0.653	<.001	18	view →
LUAD	OS	Tertile	III,IV	0.156	0.690	<.001	18	view →
CESC	DFS	Tertile	II,III,IV	0.087	0.503	.021	18	view →
SARC	OS	Tertile	All	0.980	0.824	.018	12	view →
BLCA	OS	Tertile	IV	0.210	0.487	.028	9	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

OR1I1–CHOL (OS)

Open the CHOL breakdown →