OR1I1

Across TCGA cell cohorts, OR1I1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR1I1-associated genes across cancer lineages are OR8B12, RD3L, and SIGLEC8. Each is linked with OR1I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1I1-to-partner and partner-to-OR1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by OR1I1-low versus OR1I1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1I1→partner) and Y-score (partner→OR1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	1
LUNG_SCLC	RD3L →	+0.018	+5.029	.004	.006	3	1
BREAST	SIGLEC8 →	+0.006	+5.169	<.001	.005	3	1
CNS	HELT →	+0.037	+5.321	<.001	.005	3	1
CNS	DEFB133 →	+0.046	+6.357	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR10H2 →	+0.030	+4.371	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR8B12 by OR1I1 expression — LUNG_SCLC

Explore this box plot interactively →