OR1F1

Across TCGA cell cohorts, OR1F1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1F1-associated genes across cancer lineages are KRT28, EDDM3B, and EDDM3A. Each is linked with OR1F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1F1-to-partner and partner-to-OR1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT28 grouped by OR1F1-low versus OR1F1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1F1→partner) and Y-score (partner→OR1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT28 →	+0.006	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	EDDM3B →	+0.059	+4.734	.001	.002	3	1
LUNG_NSCLC_LUAD	EDDM3A →	+0.102	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	SRY →	+0.039	+4.544	.007	.003	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.027	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.267	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KRT28 by OR1F1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →