OR1F1

Across TCGA pan-cancer cohorts, OR1F1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OR1F1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR1F1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR1F1 is over-expressed in tumor.

HNSC, LUSC, and UCEC are the cancer types where OR1F1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR1F1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.350	<.001	11	view →
LUSC	All	All	+0.291	<.001	5	view →
UCEC	All	All	+0.701	.004	4	view →
LIHC	All	All	+0.218	<.001	4	view →
BRCA	Female	II,III,IV	+0.208	<.001	4	view →
LUAD	All	All	+0.191	.001	4	view →
COAD	All	All	+0.095	.009	3	view →
KIRP	All	All	+0.065	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OR1F1–HNSC

Open the HNSC breakdown →