OR1E2

Across TCGA patient cohorts, OR1E2 mutation is significantly associated with the RNA expression of many other genes, with 1,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1E2-associated genes across cancer lineages are RPL23AP89, FCF1P8, and IGKV3-34. Each is linked with OR1E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1E2-to-partner and partner-to-OR1E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP89 grouped by OR1E2-low versus OR1E2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1E2→partner) and Y-score (partner→OR1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP89 →	+0.237	+4.032	<.001	.005	3	2
COAD	FCF1P8 →	+0.433	+3.931	<.001	.004	3	2
COAD	IGKV3-34 →	+0.195	+4.721	<.001	.004	3	2
UCEC	RNU6-668P →	+0.203	+2.864	<.001	.003	3	2
SKCM	DNAJB8 →	+0.017	+3.838	<.001	.006	3	1
SKCM	RNA5SP336 →	+0.249	+5.039	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

RPL23AP89 by OR1E2 expression — SKCM

Explore this box plot interactively →