Q-omics provides the consensus-scored IGKV3-34 profile across patient tissues and cancer cell-line models. IGKV3-34 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, IGKV3-34 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, IGKV3-34 RNA expression shows 5,176 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight STAD, COAD, and ESCA as cancer lineages where IGKV3-34 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGKV3-34 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGKV3-34 survival associations across molecular data types. IGKV3-34 RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGKV3-34 RNA expression–survival associations across cancer types. High IGKV3-34 expression shows unfavorable associations in STAD, LUAD, LUSC, COAD, SKCM and KIRC. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify STAD as the clearest survival context for IGKV3-34 RNA expression.
This table summarizes IGKV3-34 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for IGKV3-34. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGKV3-34 shows lower tumor expression in COAD and higher tumor expression in LUAD. The COAD box plot shows higher IGKV3-34 RNA expression in normal versus tumor tissue (log2 FC = −0.185, t-test p = .004).
This table shows molecular features associated with IGKV3-34 in patient tissues and cancer cell lines. In patient samples, IGKV3-34 shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set.
