IGKV3-34

Across TCGA pan-cancer cohorts, IGKV3-34 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGKV3-34 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher IGKV3-34 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3-34 expression acts as an unfavorable survival marker, although some lineages such as PAAD show a favorable association.

STAD, LUAD, and LUSC are the cancer types where IGKV3-34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	IV	0.001	0.544	<.001	72	view →
LUAD	DFS	Tertile	II,III,IV	0.269	0.535	.002	69	view →
LUSC	OS	Tertile	II,III,IV	0.151	0.557	.007	48	view →
SKCM	OS	Tertile	II,III,IV	0.187	0.843	<.001	18	view →
COAD	OS	Tertile	III,IV	0.144	0.703	.002	18	view →
KIRC	DFS	Tertile	All	0.281	0.635	.029	6	view →
PAAD	OS	Tertile	All	0.908	0.596	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGKV3-34–STAD (OS)

Open the STAD breakdown →