IGKV3-34

Across TCGA patient cohorts, IGKV3-34 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,562 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV3-34-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and B cell differentiation. Each is linked with IGKV3-34 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGKV3-34-to-partner and partner-to-IGKV3-34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV3-34-low versus IGKV3-34-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-34→partner) and Y-score (partner→IGKV3-34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.134	+0.021	<.001	.001	3	9
THCA	Immunoglobulin production →	+0.102	+0.041	<.001	<.001	3	9
STAD	B cell differentiation →	+0.105	+0.054	<.001	.001	3	9
THCA	Antimicrobial humoral response →	+0.145	+0.040	<.001	.001	3	8
STAD	Lymphocyte homeostasis →	+0.123	+0.044	<.001	.001	3	8
STAD	Antigen receptor-mediated signaling pathway →	+0.115	+0.042	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

B cell mediated immunity by IGKV3-34 expression — THCA

Explore this box plot interactively →