OR1D4

Across TCGA patient cohorts, OR1D4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR1D4-associated genes across cancer lineages are NF-kB-p65_pS536, P-Cadherin, and Smac. Each is linked with OR1D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1D4-to-partner and partner-to-OR1D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by OR1D4-low versus OR1D4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1D4→partner) and Y-score (partner→OR1D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF-kB-p65_pS536 →	-0.574	-3.321	.004	.010	3	1
SKCM	P-Cadherin →	+0.389	+3.321	.003	.010	3	1
SKCM	Smac →	+0.337	+2.186	.016	.034	2	1
SKCM	GSK-3a-b_pS21_S9 →	-0.582	-3.321	.007	.010	1	1
SKCM	Rictor_pT1135 →	-0.210	-3.304	.008	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NF-kB-p65_pS536 by OR1D4 expression — SKCM

Explore this box plot interactively →