OR1D4

Across TCGA pan-cancer cohorts, OR1D4 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated OR1D4 data layer compared with 6 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OR1D4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR1D4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

BLCA, HNSC, and KICH are the cancer types where OR1D4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.176	0.551	<.001	120	view →
HNSC	OS	Tertile	II,III,IV	0.687	0.332	.003	69	view →
KICH	OS	Tertile	All	0.155	0.926	<.001	63	view →
LIHC	OS	Tertile	All	0.128	0.704	.011	27	view →
THYM	DFS	Tertile	All	0.050	0.885	<.001	24	view →
READ	OS	Tertile	All	0.685	0.932	.011	24	view →
LUAD	DFS	Tertile	IV	0.223	0.710	.043	18	view →
PCPG	DFS	Tertile	All	0.401	0.775	.012	18	view →
LAML	DFS	Tertile	All	0.215	0.498	.040	18	view →
SKCM	DFS	Tertile	III,IV	0.162	0.548	.023	15	view →
LUSC	OS	Tertile	III,IV	0.196	0.670	.042	9	view →
KIRP	DFS	Tertile	All	0.277	0.867	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

OR1D4–BLCA (OS)

Open the BLCA breakdown →