Across TCGA pan-cancer cohorts, OR1D4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR1D4’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where OR1D4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR1D4 is over-expressed in tumor.
BRCA are the cancer types where OR1D4 tumor–normal differential expression is most reproducible.