OPN5

Across TCGA cell cohorts, OPN5 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OPN5-associated genes across cancer lineages are OR1L6, GDF2, and CCL18. Each is linked with OPN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN5-to-partner and partner-to-OPN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by OPN5-low versus OPN5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN5→partner) and Y-score (partner→OPN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	GDF2 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L6 by OPN5 expression — LUNG_SCLC

Explore this box plot interactively →