OPN5

Across TCGA pan-cancer cohorts, OPN5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OPN5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OPN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OPN5 is over-expressed in tumor.

THCA, KIRP, and STAD are the cancer types where OPN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.081	<.001	9	view →
KIRP	All	All	+0.071	.016	3	view →
STAD	Male	III,IV	+0.021	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

OPN5–THCA

Open the THCA breakdown →