OPN5

Across TCGA pan-cancer cohorts, OPN5 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated OPN5 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher OPN5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OPN5 expression acts as an unfavorable survival marker, although some lineages such as DLBC and BRCA show a favorable association.

UVM, COAD, and ACC are the cancer types where OPN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.357	0.807	<.001	47	view →
COAD	DFS	Tertile	All	0.233	0.562	.002	36	view →
ACC	DFS	Median	III,IV	0.477	0.759	.016	24	view →
LUAD	DFS	Tertile	IV	0.475	0.785	.020	18	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
READ	DFS	Tertile	IV	0.179	0.936	.010	15	view →
STAD	OS	Tertile	II,III,IV	0.382	0.614	.011	12	view →
DLBC	DFS	Tertile	All	0.858	0.486	.024	12	view →
KIRC	DFS	Median	All	0.501	0.699	.001	12	view →
BRCA	DFS	Median	All	0.968	0.938	.033	6	view →
MESO	OS	Tertile	IV	0.212	0.693	.040	6	view →
BLCA	DFS	Tertile	III,IV	0.532	0.315	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

OPN5–UVM (OS)

Open the UVM breakdown →