OPN4

Across TCGA patient cohorts, OPN4 protein abundance is significantly associated with the protein abundance of many other proteins, with 1,271 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OPN4-associated proteins across cancer lineages are TLN1_S2279, USP8_S16, and VSIG4. Each is linked with OPN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN4-to-partner and partner-to-OPN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OPN4 versus TLN1_S2279 in GBM, with a Pearson correlation of 0.93.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN4→partner) and Y-score (partner→OPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TLN1_S2279 →	+2.733	+1.110	.001	.002	3	1
GBM	USP8_S16 →	+1.106	+1.493	.002	<.001	3	1
GBM	VSIG4 →	+1.723	+1.110	.007	.002	3	1
GBM	YWHAH_S145 →	+3.889	+1.493	<.001	<.001	3	1
GBM	RFX2_S171 →	-1.163	-1.493	.003	<.001	3	1
GBM	ROCK1_S576 →	+1.603	+1.493	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

OPN4 vs TLN1_S2279 — GBM

Explore this scatter interactively →