OPN4

Across TCGA pan-cancer cohorts, OPN4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated OPN4 data layer compared with 7 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher OPN4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OPN4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

BRCA, SKCM, and KIRC are the cancer types where OPN4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.439	0.586	.001	66	view →
SKCM	OS	Median	All	0.276	0.384	<.001	60	view →
KIRC	DFS	Quartile	III,IV	0.294	0.580	.001	59	view →
CESC	DFS	Median	All	0.778	0.860	.007	42	view →
HNSC	DFS	Median	IV	0.717	0.568	.003	37	view →
KIRP	OS	Median	All	0.520	0.827	<.001	35	view →
UVM	DFS	Tertile	III,IV	0.204	1.000	.004	33	view →
MESO	OS	Median	All	0.235	0.726	<.001	33	view →
BLCA	OS	Median	III,IV	0.278	0.434	.001	23	view →
PAAD	OS	Median	All	0.325	0.536	.008	17	view →
UCS	DFS	Tertile	IV	0.981	0.714	.042	12	view →
LUSC	OS	Median	III,IV	0.774	0.581	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

OPN4–BRCA (DFS)

Open the BRCA breakdown →