OPN3

Across TCGA cell cohorts, OPN3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPN3-associated genes across cancer lineages are REG1B, LRRC3C, and TBC1D3. Each is linked with OPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN3-to-partner and partner-to-OPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by OPN3-low versus OPN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN3→partner) and Y-score (partner→OPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1
LARGE_INTESTINE	LRRC3C →	+0.395	+3.777	<.001	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.075	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	MBD3L4 →	+0.013	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

REG1B by OPN3 expression — LARGE_INTESTINE

Explore this box plot interactively →