OPN1LW

Across TCGA patient cohorts, OPN1LW mutation is significantly associated with the RNA expression of many other genes, with 826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN1LW-associated genes across cancer lineages are CDK8P1, LINC01943, and CRYBB2P1. Each is linked with OPN1LW in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN1LW-to-partner and partner-to-OPN1LW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK8P1 grouped by OPN1LW-low versus OPN1LW-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN1LW→partner) and Y-score (partner→OPN1LW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDK8P1 →	+0.341	+5.044	<.001	.009	3	2
UCEC	LINC01943 →	+0.501	+2.119	<.001	.003	3	1
UCEC	CRYBB2P1 →	+0.449	+2.108	.003	.003	3	1
UCEC	CENPM →	+0.561	+3.332	.006	.005	3	1
UCEC	PACSIN2 →	+0.534	+2.584	<.001	.001	3	1
UCEC	HMOX1 →	+0.955	+3.258	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

CDK8P1 by OPN1LW expression — LUAD

Explore this box plot interactively →