OPN1LW

Across TCGA pan-cancer cohorts, OPN1LW RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated OPN1LW data layer compared with 4 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OPN1LW RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OPN1LW expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

BLCA, SCLC, and UVM are the cancer types where OPN1LW RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.318	0.638	<.001	81	view →
SCLC	DFS	Tertile	All	0.164	0.826	<.001	45	view →
UVM	DFS	Quartile	All	0.318	0.865	<.001	37	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	28	view →
KICH	DFS	Tertile	All	0.521	0.969	.037	27	view →
READ	DFS	Tertile	All	0.292	0.852	<.001	27	view →
TGCT	DFS	Tertile	III,IV	0.017	0.923	.021	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
GBM	OS	Tertile	All	0.121	0.415	.042	9	view →
HNSC	OS	Tertile	III,IV	0.925	0.712	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

OPN1LW–BLCA (OS)

Open the BLCA breakdown →