OPN1LW

Across TCGA pan-cancer cohorts, OPN1LW RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OPN1LW’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OPN1LW RNA is repressed in tumor relative to normal tissue. In most cancer types OPN1LW is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where OPN1LW tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPN1LW RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.010	.009	5	view →
KICH	Male	II,III,IV	−0.038	.020	4	view →
UCEC	All	IV	+0.115	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

OPN1LW–KIRC

Open the KIRC breakdown →