OPN1LW

Across TCGA patient cohorts, OPN1LW mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN1LW-associated genes across cancer lineages are Stathmin, JNK_pT183_Y185, and MSH6. Each is linked with OPN1LW in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN1LW-to-partner and partner-to-OPN1LW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by OPN1LW-low versus OPN1LW-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN1LW→partner) and Y-score (partner→OPN1LW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.138	+3.321	.017	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.186	-2.321	.009	.034	3	1
UCEC	MSH6 →	-0.462	-3.321	<.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.174	-3.302	.005	.010	3	1
UCEC	Notch1 →	+0.229	+1.750	<.001	.049	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.395	-2.584	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Stathmin by OPN1LW expression — UCEC

Explore this box plot interactively →