OPCML-IT2

Across TCGA pan-cancer cohorts, OPCML-IT2 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated OPCML-IT2 data layer.

The strongest signal is observed in thymoma (THYM), where higher OPCML-IT2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OPCML-IT2 expression acts as an unfavorable survival marker.

THYM, KICH, and OV are the cancer types where OPCML-IT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.068	0.977	<.001	72	view →
KICH	DFS	Tertile	II,III,IV	0.035	0.860	<.001	36	view →
OV	OS	Tertile	II,III,IV	0.415	0.694	.013	36	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
LUSC	OS	Tertile	All	0.350	0.728	.021	27	view →
KIRP	OS	Tertile	All	0.216	0.904	<.001	27	view →
BRCA	DFS	Tertile	II,III,IV	0.155	0.520	.030	24	view →
LAML	DFS	Tertile	All	0.167	0.583	.009	18	view →
THCA	OS	Tertile	All	0.375	0.948	.027	12	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

OPCML-IT2–THYM (OS)

Open the THYM breakdown →