OPCML-IT2

Across TCGA pan-cancer cohorts, OPCML-IT2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OPCML-IT2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where OPCML-IT2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OPCML-IT2 is over-expressed in tumor.

BRCA are the cancer types where OPCML-IT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPCML-IT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.045	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

OPCML-IT2–BRCA

Open the BRCA breakdown →