OLFML3

Across TCGA patient cohorts, OLFML3 mutation is significantly associated with the RNA expression of many other genes, with 2,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFML3-associated genes across cancer lineages are HSPD1P18, TRIM53CP, and CDRT15P8. Each is linked with OLFML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFML3-to-partner and partner-to-OLFML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P18 grouped by OLFML3-low versus OLFML3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML3→partner) and Y-score (partner→OLFML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPD1P18 →	+0.532	+4.870	<.001	.002	3	2
UCEC	TRIM53CP →	+0.378	+2.220	.001	<.001	3	2
READ	CDRT15P8 →	+0.125	+5.421	<.001	.005	3	1
SKCM	ZNF479 →	+0.050	+4.669	<.001	<.001	3	1
SKCM	ZNF849P →	+0.182	+4.022	<.001	.003	3	1
SKCM	RNU6-228P →	+0.753	+3.884	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,789 associations by consensus.

HSPD1P18 by OLFML3 expression — COAD

Explore this box plot interactively →