OLFML3

Across TCGA pan-cancer cohorts, OLFML3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated OLFML3 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OLFML3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated OLFML3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

UCEC, LGG, and UCS are the cancer types where OLFML3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.879	0.732	<.001	56	view →
LGG	DFS	Median	All	0.302	0.520	<.001	53	view →
UCS	DFS	Median	III,IV	0.595	0.223	<.001	52	view →
BLCA	OS	Median	II,III,IV	0.551	0.668	.007	29	view →
SKCM	OS	Tertile	II,III,IV	0.401	0.275	.002	28	view →
STAD	OS	Quartile	All	0.501	0.701	.001	24	view →
UVM	DFS	Median	All	0.415	0.791	<.001	21	view →
MESO	DFS	Tertile	IV	0.702	0.195	.001	15	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	9	view →
ACC	DFS	Median	III,IV	0.125	0.569	.010	9	view →
OV	OS	Quartile	II,III,IV	0.793	0.873	.027	8	view →
CHOL	DFS	Tertile	All	0.787	0.135	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

OLFML3–UCEC (DFS)

Open the UCEC breakdown →