ODF2L

Across TCGA patient cohorts, ODF2L mutation is significantly associated with the RNA expression of many other genes, with 3,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODF2L-associated genes across cancer lineages are SAP30-DT, AP1S3, and ZNF367. Each is linked with ODF2L in more than 1 cancer types. Because this analysis shows association rather than direction, both ODF2L-to-partner and partner-to-ODF2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAP30-DT grouped by ODF2L-low versus ODF2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODF2L→partner) and Y-score (partner→ODF2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAP30-DT →	+0.266	+2.103	.009	.003	3	2
UCEC	AP1S3 →	+0.477	+2.247	<.001	.001	3	2
UCEC	ZNF367 →	+0.676	+2.684	<.001	<.001	3	2
UCEC	MELK →	+0.721	+4.098	<.001	<.001	3	2
UCEC	CENPN →	+0.738	+2.191	<.001	<.001	3	2
UCEC	PBK →	+0.818	+1.903	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,236 associations by consensus.

SAP30-DT by ODF2L expression — UCEC

Explore this box plot interactively →