ODF2L

Across TCGA pan-cancer cohorts, ODF2L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ODF2L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ODF2L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ODF2L is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where ODF2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ODF2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.655	<.001	10	view →
KICH	Female	II,III,IV	−1.890	<.001	9	view →
BLCA	All	III,IV	+1.013	<.001	9	view →
CHOL	Male	All	+2.273	<.001	4	view →
STAD	All	All	+0.625	.002	4	view →
COAD	Male	All	+0.338	.019	4	view →
LUAD	All	All	+0.330	.004	4	view →
ESCA	All	All	+0.704	.026	2	view →
KIRP	All	IV	+0.612	.035	2	view →
PRAD	All	All	−0.250	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ODF2L–HNSC

Open the HNSC breakdown →