NXF5

Across TCGA patient cohorts, NXF5 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXF5-associated genes across cancer lineages are JNK_pT183_Y185, Cyclin-E1, and Di-Ras3. Each is linked with NXF5 in more than 3 cancer types. Because this analysis shows association rather than direction, both NXF5-to-partner and partner-to-NXF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NXF5-low versus NXF5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF5→partner) and Y-score (partner→NXF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK_pT183_Y185 →	-0.363	-2.982	.003	.034	3	4
LUAD	Cyclin-E1 →	+0.281	+2.000	.010	.031	3	3
UCEC	Di-Ras3 →	-0.172	-2.754	<.001	<.001	3	3
UCEC	PDCD4 →	-0.578	-1.777	<.001	.002	3	3
UCEC	Cyclin-B1 →	+0.821	+2.378	<.001	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.382	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

JNK_pT183_Y185 by NXF5 expression — COAD

Explore this box plot interactively →