NXF5

Across TCGA cell cohorts, NXF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,011 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NXF5-associated GO terms across cancer lineages are Regulation of termination of RNA polymerase II transcription, Regulation of termination of DNA-templated transcription, and Negative regulation of mitotic cell cycle phase transition. Each is linked with NXF5 in more than 4 cancer types. Because this analysis shows association rather than direction, both NXF5-to-partner and partner-to-NXF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of termination of RNA polymerase II transcription grouped by NXF5-low versus NXF5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF5→partner) and Y-score (partner→NXF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of termination of RNA polymerase II transcription →	+0.084	+0.009	.001	.001	3	4
SKIN	Regulation of termination of DNA-templated transcription →	+0.084	+0.009	.001	.001	3	4
LUNG_SCLC	Negative regulation of mitotic cell cycle phase transition →	+0.042	+0.049	.002	.003	3	4
LUNG_SCLC	Post-Golgi vesicle-mediated transport →	+0.045	+0.034	.005	.007	2	5
LUNG_SCLC	Aromatic amino acid metabolic process →	-0.138	-0.045	<.001	.007	3	4
BLOOD_Myeloma	Phosphatidylinositol phosphate biosynthetic process →	+0.041	+0.130	.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,011 associations by consensus.

Regulation of termination of RNA polymerase II transcription by NXF5 expression — SKIN

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