NXF1

Across TCGA cell cohorts, NXF1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NXF1-associated genes across cancer lineages are CORIN, ALOXE3, and ADAM7. Each is linked with NXF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXF1-to-partner and partner-to-NXF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORIN grouped by NXF1-low versus NXF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF1→partner) and Y-score (partner→NXF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CORIN →	+0.136	+3.371	.002	.005	3	2
BLOOD_Leukemia	ALOXE3 →	+0.292	+3.817	<.001	.002	3	2
BLOOD_Leukemia	ADAM7 →	+0.014	+3.185	.001	.006	3	2
LARGE_INTESTINE	SKA1 →	+0.875	+3.067	.004	.009	3	2
BLOOD_Leukemia	ELOVL4 →	+2.486	+3.392	<.001	.007	3	1
BLOOD_Leukemia	VSX2 →	+0.024	+3.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

CORIN by NXF1 expression — BLOOD_Leukemia

Explore this box plot interactively →