NXF1

Across TCGA pan-cancer cohorts, NXF1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NXF1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NXF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NXF1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, HNSC, and COAD are the cancer types where NXF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NXF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.105	<.001	9	view →
HNSC	Male	All	+0.469	<.001	9	view →
COAD	Female	All	+0.484	<.001	8	view →
KICH	Female	All	−0.798	<.001	6	view →
STAD	Male	II,III,IV	+0.790	.010	4	view →
CHOL	Male	All	+1.621	<.001	3	view →
KIRC	Female	All	+0.450	.002	2	view →
THCA	All	All	+0.245	.023	2	view →
ESCA	All	All	+0.408	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NXF1–LIHC

Open the LIHC breakdown →