NUP98

Across TCGA cell cohorts, NUP98 mutation is significantly associated with the RNA expression of many other genes, with 996 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP98-associated genes across cancer lineages are NOBOX, OR6B3, and TBC1D3. Each is linked with NUP98 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP98-to-partner and partner-to-NUP98 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by NUP98-low versus NUP98-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP98→partner) and Y-score (partner→NUP98) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NOBOX →	+0.004	+4.662	<.001	.003	3	2
BLOOD_Lymphoma	OR6B3 →	+0.030	+3.523	<.001	.009	3	2
SKIN	TBC1D3 →	+0.780	+3.297	<.001	.002	3	2
CNS	SPATA48 →	+0.013	+3.772	<.001	.008	3	2
BLOOD_Leukemia	ZNF286A →	+1.371	+3.307	.001	.004	3	2
BLOOD_Leukemia	USP17L17 →	+0.002	+3.569	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 996 associations by consensus.

NOBOX by NUP98 expression — BLOOD_Lymphoma

Explore this box plot interactively →