NUP98

Across TCGA pan-cancer cohorts, NUP98 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NUP98’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NUP98 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUP98 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, STAD, and HNSC are the cancer types where NUP98 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUP98 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.568	<.001	9	view →
STAD	Male	II,III,IV	+1.057	<.001	8	view →
HNSC	Male	All	+0.645	<.001	8	view →
LIHC	All	II,III,IV	+0.605	<.001	8	view →
THCA	All	All	−0.367	<.001	7	view →
CHOL	All	All	+1.227	<.001	5	view →
KICH	All	All	−0.682	.001	3	view →
PRAD	All	All	+0.229	.027	2	view →
LUSC	All	All	+0.227	.014	2	view →
ESCA	Female	All	+1.036	.032	1	view →
COAD	Female	IV	−0.265	.010	1	view →
KIRC	All	All	+0.172	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

NUP98–COAD

Open the COAD breakdown →