NUP43

Across TCGA patient cohorts, NUP43 mutation is significantly associated with the RNA expression of many other genes, with 414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP43-associated genes across cancer lineages are MIR1273H, IFITM3P7, and RNU6-451P. Each is linked with NUP43 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP43-to-partner and partner-to-NUP43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1273H grouped by NUP43-low versus NUP43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP43→partner) and Y-score (partner→NUP43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1273H →	+0.237	+3.036	<.001	.009	3	2
LUAD	IFITM3P7 →	+0.266	+3.667	<.001	.007	3	2
UCEC	RNU6-451P →	+0.561	+2.801	<.001	.005	3	2
UCEC	RNU6-66P →	+0.263	+3.750	<.001	.002	3	2
UCEC	IGKJ5 →	+2.625	+3.470	<.001	.003	3	2
UCEC	TRAJ47 →	+0.696	+3.105	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 414 associations by consensus.

MIR1273H by NUP43 expression — UCEC

Explore this box plot interactively →