NUP43

Across TCGA pan-cancer cohorts, NUP43 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NUP43’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NUP43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NUP43 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where NUP43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUP43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.946	<.001	11	view →
BLCA	All	III,IV	+0.698	<.001	11	view →
COAD	Female	II,III,IV	+1.012	<.001	10	view →
LIHC	Female	II,III,IV	+1.140	<.001	9	view →
LUAD	Male	II,III,IV	+0.813	<.001	9	view →
STAD	Male	II,III,IV	+1.202	<.001	8	view →
LUSC	Female	All	+1.016	<.001	8	view →
BRCA	All	III,IV	+0.566	<.001	8	view →
KICH	Female	II,III,IV	−1.358	<.001	7	view →
READ	All	All	+0.891	<.001	7	view →
KIRP	All	IV	+0.872	.001	7	view →
UCEC	All	All	+0.504	.002	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NUP43–HNSC

Open the HNSC breakdown →