NUP153

Across TCGA cell cohorts, NUP153 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP153-associated genes across cancer lineages are NCR1, SERPINA4, and FSHB. Each is linked with NUP153 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP153-to-partner and partner-to-NUP153 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCR1 grouped by NUP153-low versus NUP153-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP153→partner) and Y-score (partner→NUP153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NCR1 →	+0.064	+4.029	<.001	.009	3	2
BLOOD_Myeloma	SERPINA4 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FSHB →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRT85 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2M2 →	+0.033	+4.807	<.001	.006	3	1
OESOPHAGUS	IL22 →	+0.031	+4.115	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

NCR1 by NUP153 expression — OVARY

Explore this box plot interactively →